How a Sense of Collective Efficacy Influences Teacher Learning during Change: The Role of Academic Optimism and Shared Vision

Purpose: The purpose of this study is twofold. First, this study reflects on the development of professional capital through understanding collective cultural factors, namely, academic optimism and shared vision. Second, it aims at exploring teacher learning. Teacher learning resulting in changes to teacher knowledge, attitudes and practices is crucial for the necessary changes education is continually confronted with. This learning is too often studied as a result of individual traits or structural factors, such as motivation or time. The authors investigated how teacher learning is influenced by academic optimism and shared vision. Design/methodology/approach: The authors administered an online web-based survey to 278 teachers in higher education, using the educational change to online learning due to the COVID pandemic as a unique chance to study the role of collective cultural factors in teacher learning. Findings: Results showed how teachers characterized their learning, academic optimism and shared vision during the educational change to online learning resulting from the COVID pandemic. The authors found that teacher learning was greatly influenced by teachers' collective sense of efficacy, an aspect of their academic optimism. Teachers' strong belief in each other, that they as fellow professionals could handle the challenging changes that the COVID pandemic required, strongly enhanced teacher learning during the COVID pandemic. Teachers' feeling of a professional community helped teacher to make sense of, and push through, the undeniable chaos that was the COVID pandemic. Originality/value: Collective cultural factors are rarely studied in conjunction with educational change. Insights into how a collective culture of professionalism enhances or hinders teacher learning are important for theory, policy and practice as it helps understand how teacher teams can be supported to build their professional capital by learning from educational change.

ENgagENYOY: A digital transdiagnostic clinical - and peermoderated treatment platform for youth with mental health complaints in the Netherlands

The onset of mental disorders typically occurs between the ages of 12 and 25, and the burden of mental health problems is the most consequential for this group. Indicated prevention interventions to target individuals with subclinical symptoms to prevent the transition to clinical levels of disorders, even leading to suicide, have shown to be effective. However, the threshold to seek help appears to be high. Digital interventions could offer a solution, especially during the Covid-19 pandemic. In this talk, the presenters will take you on a journey through the background, effects and experience of the digital indicated prevention intervention ENgage YOung people Early (ENYOY). ENYOY specifically addresses young people with emerging mental health complaints, and offers a new approach for treatment in the Netherlands through a clinical- and peer- moderated treatment platform. Considering the waiting lists in (child and adolescent)- psychiatry and the increase in suicides amongst youth, early lowthreshold and non-stigmatizing help to support young people with emerging psychiatric symptoms is of crucial importance. Moreover, this project aims to bridge the gap between child and adolescent and adult psychiatry. We included 125 young people with subclinical mental health problems (stage 1b), age 16-25 years. Using a combined peer and clinical support approach participants followed their personalized digital therapeutic treatment journey for up to 12 months. The first results demonstrate that at 3 and 6 months follow-up complaints significantly decrease (K-10) and social functioning increase (SOFAS) (p < .05). This new approach may offer perspective for young people and the healthcare system.

A Literature Review Assessing the Most Common Attributes Used in Stated-Preference Studies Assessing Influenza Vaccination: Do We Know What Health Care Professionals Value?

Objectives: Several attributes may be important in flu vaccine and since Covid-19, the role of health care professionals (HCPs) may have become more important in increasing flu vaccine uptake. We conducted a literature review to assess if previous preference research could inform future flu vaccination policies. Method(s): We conducted a literature review to assess the most common attributes used in stated-preference studies to determine seasonal flu vaccination preferences. PubMed with key terms such as "discrete choice", "stated preference" and "flu/vaccin*" was used to retrieve relevant research. Result(s): In total, twelve studies investigating consumer and HCP preferences for flu vaccines using a discrete-choice experiment were included. Six studies were conducted in vaccine-eligible populations, three were conducted with parents (specifically, two focused on older adults and one elicited preferences directly from HCPs in Hong Kong). Three studies were conducted in the Netherlands, two in Japan and four in China. Vaccine efficacy was most often framed in terms of percentage (n=7). Out of pocket cost and duration of immunity were common attributes. Source of recommendation for vaccination (i.e., regulatory or public health body) was assessed in 25% of the studies. In studies assessing parental preferences for their children influenza vaccination, risks of fewer side effects were, unsurprisingly, preferred. Finally, among HCPs, vaccine effectiveness and vaccination location (staff clinic/mobile vaccination center) were most important and could increase the probability of vaccination. Conclusion(s): Information incompleteness and asymmetry could play a role in vaccine hesitation and/or aversion. To increase vaccination rates, evidence on the attributes perceived to be important to both HCPs and the general population may help the design and delivery of vaccines that match consumers' preferences. Currently, there is a critical need for more stated-preference studies among HCPs to better understand the attributes likely to increase vaccination rates against seasonal influenza.Copyright © 2023

Carving a Path Toward Global Implementation of eConsent in Clinical Trials

[...]countries do not always recognize and allow electronic signatures. In many cases, this calls for a complete revision of existing laws and regulations;it has already been done in the past for some technologies, including the regulation of electronic signatures, but much more important revisions, such as the third revision of International Conference on Harmonization Good Clinical Practice (ICH GCP), are underway for the complete integration of the various aspects of emerging technologies.7 In the scope of our research project, titled "Toward a Global Implementation of eConsent in Clinical Trials," a survey was conducted to understand how eConsent is perceived and experienced by clinical research experts, how it can improve patient comprehension and reduce site burden, as well as to identify areas of opportunities and challenges for further adoption. [...]when stakeholders were asked what the main barrier limiting the implementation of eConsent at their organization is, many sponsors explained that the fragmented guidelines and regulations had considerably hindered their use of eConsent. [...]it requires staff training and adaptation and, here again, the fragmented or-in some cases-even lack of regulation around eConsent makes it difficult to implement on sites.

Frontrunners in Organ-on-a-Chip

Advances in tissue engineering, microfabrication, and biocompatible microfluidic chambers alongside the governmental (2) and regulatory (3) appetite to seek animal-free innovations in the drug development process has fuelled further interest and investment in this marketplace. According to market research, the global O°C market is forecast to be worth US$388 million (€354 million) by 2028 increasing from US$82 million (€75 million) in 2023, with a compound average growth of 36.4% from 2023 to 2028 (4). In March 2022, Lyon-based NETRI, attracted €8 million series A funding to help develop its novel high throughput (HT) compartmentalized microfluidic brain-on-a-chip and skin-on-a-chip technology for use by the pharma and cosmetic industry (15). Global Organ-onChip Market Size, Share, Trends, COVID-19 Impact and Growth Analysis ReportSegmented by Type (Heart-on-chip, Humanon-chip, Intestine-on-chip, Kidney-on-chip, Liver-on-chip and Lung-on-chip), Application and Region (North America, Europe, AsiaPacific, Latin America, Middle East and Africa)-Industry Forecast from 2023 to 2028.

Geographic Information Systems for Facilitating Audits of the Urban Built Environment

Data collection and large-scale urban audits are challenging and can be time consuming processes. Geographic information systems can extract and combine relevant data that can be used as input to calculation tools that provide results and quantify indicators with sufficient spatial analysis to facilitate the local decision-making process for building renovations and sustainability assessment. This work presents an open-access tool that offers an automated process that can be used to audit an urban area in order to extract relevant information about the characteristics of the built environment, analyze the building characteristics to evaluate energy performance, assess the potential for the installation of photovoltaics on available building rooftops, and quantify ground permeability. A case study is also presented to demonstrate data collection and processing for an urban city block, and the relevant results are elaborated upon. The method is easily replicable and is based on open data and non-commercial tools.

Sex Workers' Everyday Security in the Netherlands and the Impact of COVID-19.

Introduction: The COVID-19 pandemic has laid bare and exacerbates the existing insecurities of sex workers. This paper asks: What are sex workers' everyday experiences of (in)security? And: How has the COVID-19 pandemic influenced these? Methods: We engage with these questions through collaborative research based on semi-structured interviews carried out in 2019 and 2020 with sex workers in The Hague, the Netherlands. Results: Revealing a stark mismatch between the insecurities that sex workers' experience and the concerns enshrined in regulation, our analysis shows that sex workers' everyday insecurities involve diverse concerns regarding their occupational safety and health, highlighting that work insecurity is more multi-faceted than sexually transmitted infections (STIs). Widespread employment and income insecurities for sex workers are exacerbated for transwomen and male sex workers. Their legal liminality is enabled not only by the opaque legal status of sex work in the Netherlands, but also by the gendering of official regulation. The COVID-19 pandemic made visible how the sexual and gender norms that informally govern sex workers' working conditions intersect with hierarchies of citizenship, complicating access to COVID-19 support, particularly for migrant sex workers. Conclusions: Sex work regulation in the Netherlands leaves workers in a limbo-not without obligations and surveillance, yet, without the full guarantee of their labour rights. Policy Implications: To effectively address sex workers' insecurities, a shift in regulation from its current biopolitical focus to a labour approach is necessary. Besides, public policy and civil society actors alike need to address the sex industry's harmful social regulation through hierarchies of gender, sexuality and race.

Framing the pandemic: Multiplying "crises" in Dutch healthcare governance during the emerging COVID-19 pandemic.

In this paper we explore the impact of the emerging COVID-19 pandemic on the governance of healthcare in the Netherlands. In doing so, we re-examine the idea that a crisis necessarily leads to processes of transition and change by focusing on crisis as a specific language of organizing collective action instead. Framing a situation as a crisis of a particular kind allows for specific problem definitions, concurrent solutions and the inclusion and exclusion of stakeholders. Using this perspective, we examine the dynamics and institutional tensions involved in governing healthcare during the pandemic. We make use of multi-sited ethnographic research into the Dutch healthcare crisis organization as it responded to the COVID-19 pandemic, focusing on decision-making at the regional level. We tracked our participants through successive waves of the pandemic between March 2020 and August 2021 and identified three dominant framings of the pandemic-as-crisis: a crisis of scarcity, a crisis of postponed care and a crisis of acute care coordination. In this paper, we discuss the implications of these framings in terms of the institutional tensions that arose in governing healthcare during the pandemic: between centralized, top-down crisis management and local, bottom-up work; between informal and formal work; and between existing institutional logics.

Impact of COVID-19 on the Dutch Flower Trade-Logistics Node

Cut, cooled, packed, transported and traded all over the world, flowers represent a showcase of a worldwide integrated trade-logistics system. As one of the most perishable, vulnerable and time-critical products, speed is everything in harvesting, moving and trading of flowers. In the international trade of flowers and logistics of florticulture products, the Netherlands is the largest center of trade and logistics of flowers, taking a share of more than 40% in global cut flower export volume. When COVID-19 hit the world, this ever-moving system came to a full stop. What did this mean for the trade and logistics system? Which players were hit most? Did the crises change the system, just interrupt it or has it set the stage for developments already under way to strengthen and accelerate? This chapter presents and discusses the international position of the Dutch trade-logistics system as the most dynamic part of a worldwide flower industry. It sketches key trends in the industry over the last decade and draws a line towards possible post-COVID-19 scenarios for the worldwide flower industry and the international position of the Netherlands. The Dutch flower industry has shown incredible resilience to the external shock of COVID-19, but the crisis also has uncovered some weaknesses of the international flower industry. However, the chapter concludes that it is unlikely that these weaknesses will change the direction of developments in the sector, some of which already started to take shape in the 1970s. The chapter is based on pre-COVID-19 research and literature on the trade-logistics hub of the Netherlands, an analysis of trade and logistics data from around 2000 up to the first months of 2021, and existing economic scenarios for the flower industry and world trade. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.

Under Pandemic: Assessment of Ventilation in Secondary Schools in The Netherlands

To investigate the sufficiency of ventilation during the COVID-19 pandemic for school children, a field study was conducted in 37 classrooms of 11 Dutch secondary schools between October 2020 and June 2021. All the classrooms were visited twice, before and after a three-month national lockdown, when different measures against COVID-19 were taken by the schools. For each visit, both CO2 concentrations and air temperature were measured during school hours, and detailed information on building/classroom characteristics, occupancy, and COVID-19 measures was collected. Results show that before the lockdown, CO2 concentrations in most classrooms exceeded the threshold levels of the Dutch Fresh Schools guidelines. The significantly lower CO2 concentrations measured after the lockdown, however, were mainly due to the decreased occupancy. Moreover, with windows and doors always being opened on purpose, the performance of different ventilation regimes could not be compared, while such behaviour may also lead to thermal discomfort for school children. © 2022 17th International Conference on Indoor Air Quality and Climate, INDOOR AIR 2022. All rights reserved.

Inflammatory Profiles Are Associated with Long Covid 6 Months after Illness Onset

Background: Systemic hyperinflammation is key to the pathogenesis of severe, acute COVID-19. However, few studies have analysed inflammatory profiles in adults with mild/moderate COVID-19, or in those with post-acute sequelae of COVID-19 (PASC). We aimed to i) describe trajectories of cytokines in a prospective cohort of adults with mild to severe COVID-19, compared to uninfected, healthy controls and ii) identify early (< 4 weeks after illness onset onset) predictors of ongoing PASC and inflammation at 6 months after illness onset. Method(s): RECoVERED is a prospective cohort of adults with laboratoryconfirmed SARS-CoV-2 infection between May 2020 and June 2021 in Amsterdam, the Netherlands. Serum was collected at weeks 4, 12 and 24. Participants completed monthly symptom questionnaires. PASC was defined as having at least one ongoing symptom that originated < 1 month of illness onset. Cytokine concentrations were analysed by human magnetic Luminex screening assay. We performed random forest regression to identify early predictors of PASC and raised CRP/IL-6 at 24 weeks, using Shapley additive explanation values as measures of importance for the different predictors. Result(s): Of 349 RECoVERED participants, 186 (53%) had >=2 serum samples and were included in current analyses. Of these, 101 (54%: 45/101 [45%] female, median age 55 years [IQR=45-64]) reported PASC at 12 weeks after illness onset, of whom none recovered by 24 weeks. We included 37 uninfected controls (17/37 [46%] female, median age 49 years [IQR=40-56]). At 4 weeks after illness onset, levels of IP10, IL10, IL17, IL1beta, IL6 and TNFalpha were significantly elevated among participants infected with SARS-CoV-2 compared to controls. Ongoing PASC was independently associated with raised CRP at 24 weeks. Early raised IL1beta and sCD14 levels and greater BMI at illness onset were the strongest predictors of PASC at 24 weeks. Those with higher early sCD14 or IL1beta and TNFalpha levels were also more likely to have persistently raised CRP and IL6, respectively, at 24 weeks (Fig.1). Conclusion(s): Differences in cytokine concentrations between individuals with COVID-19 and uninfected controls largely were greatest < 4 weeks after illness onset. In our study, ongoing PASC was associated with persistently elevated CRP at 24 weeks. Early immune dysregulation was, alongside BMI, an important determinant for persistent PASC. Further investigation of individuals with PASC and long-term aberrant cytokine levels may help improve our understanding of the condition. (Figure Presented).

The Role of Media Use and Misinformation Perceptions in Optimistic Bias and Third-person Perceptions in Times of High Media Dependency: Evidence from Four Countries in the First Stage of the COVID-19 Pandemic

When societies are struck by large-scale disruptions, biases in citizens' personal risk assessment and the spread of misinformation are often reason for concern. As a contribution, this study aims to link individuals' biased perceptions of self-other asymmetry—i.e., optimistic bias in risk assessment and third-person perception regarding undesired media influence—to different patterns of news consumption and misinformation perceptions. To study these phenomena, we distributed an online survey in the early phase of the COVID-19 pandemic among citizens from the US, the UK, the Netherlands, and Germany (N = 1,912). The findings offer consistent support for bias beliefs: Compared to others, citizens from all four countries perceived themselves as less vulnerable to health and financial risk—i.e., optimistic bias—as well as the influence of misinformation—i.e., third-person perception. In a next step, we provide novel insights into how general news use can be associated with lower optimistic bias regarding perceived personal risk, while intentional exposure to issue-specific information and misinformation perceptions can relate to higher optimistic bias and third-person perceptions. These relationships were found to differ across individual countries. Overall, this study provides novel insights into how media use and perceptions relate to perceived invulnerability to potential harm, which, in turn, might impede pro-social intentions during crises surrounded by the omnipresence of misinformation. [ FROM AUTHOR] Copyright of Mass Communication & Society is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

COVID-19 VACCINATION AND HOMELESSNESS: THE NEED FOR A PERSON-CENTERED INTEGRATED APPROACH

Introduction: As homeless people in general suffer from poor health and are at elevated risk for COVID-19 infections they have an indication for receiving COVID-19 vaccination. However, several barriers in accessing vaccination can be identified. There is no information on the willingness of homeless people to receive the COVID-19 vaccination, nor on the experiences with the vaccination process of homeless people and professionals involved. Therefore, this qualitative study aims to provide insight into vaccination willingness among homeless people in the Netherlands, in the barriers and facilitators in accessing vaccination, and in the experiences of professionals involved in the vaccination process. Methods: We performed semi-structured interviews with 53 homeless persons, 16 professionals involved in health care or shelter for homeless people as well as 7 public health professionals who were involved in the vaccination process for homeless people. Interviews were thematically analyzed. Results: Homeless people experienced a lack of understandable and consistent information, which resulted in distrust and vaccination hesitancy. Mistrust in the government was common. However, approximately half of them were vaccinated at the end of the first vaccination campaign, sometimes because not being vaccinated would restrict their possibilities to access public places. Barriers to access vaccination included the complicated process and forms and difficulties accessing the vaccination venue. Especially difficult turned out to be the bureaucratic process of acquiring the Corona virus entry pass. Identified key-elements for a successful vaccination campaign for homeless people: a strong collaboration between all stakeholders, easy to understand information by trusted professionals, the possibility of vaccination at out-reach sites like homeless shelters. Conclusion: Although the vaccination rate among homeless people in the Netherlands is estimated to be lower than among the general public, successful vaccination campaigns are possible if trusted people provide easy to understand information, all stakeholders work together and vaccination takes place at easy to reach locations.

Self-Reported Changes in Personal Development and Meaning in Life among Older Adults during the COVID-19 Pandemic: Results from the Longitudinal Aging Study Amsterdam

Objectives. The aim of this study was to explore self-reported changes in personal development and meaning in life of older adults in the Netherlands during the COVID-19 pandemic and characteristics of the groups that reported these changes. Methods. Older adults from the Longitudinal Aging Study Amsterdam completed a questionnaire on the impact of the COVID-19 pandemic. Participants were asked to rate changes in personal development and meaning in life. These variables were descriptively analysed and logistic regression analyses were used to explore characteristics of the groups that reported these changes. Results. Of the 1099 older adults (aged 62–102 years), 25.7% paid more attention to things one enjoys doing in spare time, 36.6% reflected more on important things in life, and 16.8% made less future plans during the COVID-19 pandemic. Self-reported changes in meaning in life and personal development differed between specific subgroups of older adults. The largest changes in aspects of personal development and meaning in life were reported by older adults who experienced personal adverse experiences such as death of a loved one (ORs 2.03) and/or health problems such as functional limitations (ORs ranging from 1.59 to 2.84) and depression (ORs ranging from 1.69 to 2.77). Discussion and Implications. A substantial share of the participants reported changes in specific aspects of personal development and meaning in life. This was especially true for certain subgroups of older adults. Relatives and caregivers should be aware of changes in personal development and meaning in life since lower scores are known to be associated with poor physical, psychological, and social well-being outcomes.

Immune suppressant therapy is associated with improved anemia and a decrease in transfusion needs in critically ill COVID patients

Introduction: Anemia of inflammation is considered to be a main cause of anemia on the ICU. Inflammatory cytokines, most importantly IL-6, play a role in this pathogenesis. Given that both anemia and red blood cell (RBC) transfusions are associated with adverse outcomes, and iron is ineffective, novel treatments of anemia are wanted. The aim of this study is to investigate the effect of immunosuppressive agents on anemia development and RBC transfusions in critically ill COVID patients. Method(s): This retrospective cohort study included all ICU patients of two hospitals in the Netherlands between February 2020 and April 2022 with a PCR-positive COVID-19 ARDS. Actively bleeding patients were excluded. Evolving insights in the treatment protocol resulted in three treatment groups: no treatment, steroids or combination of steroids with tocilizumab. Daily lab results and number of RBC transfusion were retrieved and the decline in Hb level between ICU admission day 1 and 7 was calculated. A multiple linear regression analysis was used to compare outcomes. Result(s): In total, 719 patients were included, of which 168 in the no-treatment group, 337 in the steroid group and 212 in the steroids and tocilizumab group. Hb levels declined in all groups. The median decline in Hb level in the combination group was lowest, with -0.3 mmol/l [-0.9 to 0.2], -0.8 mmol/l [-1.3 to -0.1] in the group receiving steroids in the steroid group and [-1.6 to -0.5] in the no treatment group. The number of RBC transfusions was 1 [1-3] in the group receiving combination therapy, 3[1-6] in the group receiving steroids and 3[2-8] in the group receiving no treatment (p < 0.002). In a multivariate analysis, the receipt of combination therapy remained associated with inhibition of decline in Hb as well as with lowering the number of RBC transfusions. Conclusion(s): Treatment with either steroids or a combination of steroids and tocilizumab was associated with a slower decline in Hb levels during ICU stay and less RBC transfusions when compared to no treatment.

Covid-19 Vaccination Impacts Functional Immune Responses and Plasma Proteome in Plwh

Background: The impact of COVID-19 infection or COVID-19 vaccination on the immune system of people living with HIV (PLWH) is unclear. We therefore studied the effects of COVID-19 infection or vaccination on functional immune responses and systemic inflammation in PLWH. Method(s): Between 2019 and 2021, 1985 virally suppressed, asymptomatic PLWH were included in the Netherlands in the 2000HIV study (NCT039948350): 1514 participants enrolled after the start of the COVID-19 pandemic were separated into a discovery and validation cohort. PBMCs were incubated with different stimuli for 24 hours: cytokine levels were measured in supernatants. ~3000 targeted plasma proteins were measured with Olink Explore panel. Past COVID-19 infection was proven when a positive PCR was reported or when serology on samples from inclusion proved positive. Compared were unvaccinated PLWH with and without past COVID-19 infection, and PLWH with or without anti-COVID-19 vaccination excluding those with past COVID-19 infection. Result(s): 471 out of 1514 participants were vaccinated (median days since vaccination: 33, IQR 16-66) and 242 had a past COVID-19 infection (median days since +PCR: 137, IQR 56-206). Alcohol, smoking, drug use, BMI, age, latest CD4 count and proportion with viral blips were comparable between groups. Systemic inflammation as assessed by targeted proteomics showed 89 upregulated and 43 downregulated proteins in the vaccinated participants. In contrast, individuals with a past COVID-19 infection display lower levels of 138 plasma proteins compared to the uninfected group (see figure). 'Innate immune system' and 'cell death' were upregulated in pathway analysis in vaccinated PLWH, but downregulated in COVID-19 infected participants. The increased systemic inflammation of the COVID-19 vaccinated group was accompanied by lower TNF-alpha and IL-1beta production capacity upon restimulation with a range of microbial stimuli, while production of IL-1Ra was increased. In COVID-19 infected PLWH only a reduced production of TNF-alpha to S. pneumonia was significant. Vaccinated PLWH also showed upregulation of platelet aggregation pathways. Conclusion(s): COVID-19 vaccination in PLWH leads to an increased systemic inflammation, but less effective cytokine production capacity of its immune cells upon microbial stimulation. This pattern is different from that of COVID-19 infection that leads to a decreased inflammatory profile and only minimal effects on cytokine production capacity. (Figure Presented).

The 25th Bangkok International Symposium on HIV Medicine

Proceedings of: 25th Bangkok International Symposium on HIV Medicine, 18-20 January 2023, held virtually and on site at Samyan Mitrtown Hall, Bangkok, Thailand. The Bangkok International Symposium on HIV Medicine has commenced on the third Wednesday of January since 1998. The Symposium aims to provide professional healthcare workers in Thailand and the region an opportunity to receive the most up-to-date information on HIV and its related conditions if they are unable to attend other HIV conferences abroad. This year's hybrid symposium was held from 18 January to 20 January 2023. A total of six plenary sessions were held in the mornings, and four afternoon workshops held on Wednesday and Thursday. Expert speakers from Thailand, China, Malaysia, Singapore, India, Hong Kong, the Philippines, Australia, the UK, The Netherlands and the USA participated in the symposium.Copyright © 2023 Future Medicine Ltd.

Zooanthropogenic potential of SARS-CoV-2 virus: Implications for vaccine-mediated immunity

The human pandemic caused by Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that started in December, 2019 is still continuing in various parts of the world. The SARS-CoV-2 has evolved through sporadic mutations and recombination events and the emergence of alternate variants following adaptations in humans and human-to-animal transmission (zooanthraponosis) has raised concerns over the efficacy of vaccines against new variants. The animal reservoir of SARS-CoV-2 is unknown despite reports of SARS-CoV- 2-related viruses in bats and pangolins. A recent report of back-andforth transmission of SARS-CoV-2 between humans and minks on mink farms in the Netherlands has sparked widespread interest in zooanthroponotic transmission of SARS-CoV-2 followed by reemergence to infect human populations. The risk of animal to human transmission depends on virus-host interaction in susceptible species that may be short-term or long term risks. The short term risk might be due to infection to humans during the viremic stage in susceptible animals. The long term risk might be either due to persistence of the virus at population level or latency of infection leading to risk of evolution and re-emergence of the virus. Experimental studies have identified a range of animals that are susceptible and permissive to SARS-CoV-2 infection viz. cats, ferrets, hamsters, mink, non-human primates, tree shrews, raccoon dogs, fruit bats, and rabbits. The health impacts of SARS-CoV-2 infection in animals are unknown and it is likely that other susceptible species have not been discovered yet. Apart from farmed animals, stray cats and rodents have been identified as a potential opportunity for ongoing transmission in intense farming situations. Recognizing animal species that are most susceptible to infection is the first step in preventing ongoing transmission from humans. Minimizing the risk of zooanthraponosis requires multi-sectoral coordination that includes implementation of strict biosecurity measures such as controlled access to farms that house susceptible animals, bio-secure entry and exit protocols, disinfection protocols in farm, down time for animal transport vehicles and daily assessments of human handlers for exposure to SARS-CoV- 2. Hence, active surveillance in animal species that are prioritized based on risk assessment need to be initiated in coordination with health and environment sectors for early identification of emerging and re-emerging variants of SARS-CoV-2 virus in animals.

PERCEIVED RESILIENCE AND PATIENT SAFETY OF DUTCH NURSING STAFF DURING THE COVID-19 PANDEMIC

Background: The COVID-19 pandemic imposed enormous challenges for healthcare professionals. Nursing staff had to work under psychological pressure to maintain patient safety. Resilience has proven to be a protective psychological health factor that can safeguard healthcare professionals' mental health and well-being during healthcare crises. The state of resilience among Dutch healthcare professionals is not yet known. Objective: This study investigated perceived resilience and perception of patient safety during the COVID-19 pandemic among Dutch nursing staff. Additionally, individual differences in resilience were examined in relation to patient safety. Method: An online survey about resilience and patient safety was sent to 2,611 members of the Dutch Nursing Staff Panel in June 2021, after the third wave of the COVID-19 pandemic in the Netherlands. Results: 884 certified nursing staff professionals completed the survey (33% response rate). Nursing staff considered themselves resilient with a positive perception of patient safety within their organization. Factors that influenced resilience were education, age, part-time employment, experiences with treating patients with a COVID-19 infection, and having suffered from a COVID-19 infection. Nursing staff who perceived higher resilience reported to act more flexible during their work, to encounter more unexpected situations and they found that working according protocols and guidelines had improved during the pandemic. Discussion: The results show a more positive pattern compared to other European countries. In the Netherlands, nursing staff considered themselves as highly resilient. Conclusions: Resilient healthcare professionals report to be better able to handle crises such as the COVID-19 pandemic. Optimally, strengthening individual resilience for the healthcare organization may secure the patient safety of health care in the future.